CRMP1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90333-50, BS90333-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q14194(Human) P97427(Mouse) Q62950(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ICC IHC FC IP,

All Applications: WB:1:500-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Background: Collapsin response mediator proteins (CRMPs), including CRMP-1 (DRP-1), CRMP-2 (DRP-2 or TOAD64), CRMP-3 (DRP-4), CRMP-4 (DRP-3) and CRMP-5 (DRP-5), mediate signal transduction after exposure of neural cells to the axon guidance molecule Semaphorin 3A (SEMA3A)/collapsin. CRMPs are present in the developing cerebral cortex and neocortical neurons and are responsive to SEMA3A. In the adult brain, the expression of CRMPs is dramatically downregulated. However, they remain expressed in structures that retain their capacity for differentiation and plasticity. CRMP-1 is also involved in cancer invasion and metastasis.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: CRMP1 polyclonal antibody detects endogenous levels of CRMP1 protein.

Bioworld Molecular Weight: 74/62 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of CRMP1 on mouse brain tissue lysate using anti-CRMP1 antibody at 1/500 dilution., ICC staining CRMP1 in N2A cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: CRMP-1, ULIP-3, CRMP1, DPYSL1, ULIP3, Collapsin response mediator protein 1, CRMP 1, CRMP-1, Crmp1, Dihydropyrimidinase like 1, Dihydropyrimidinase related protein 1, Dihydropyrimidinase-related protein 1, DPYL1, DPYSL1, DRP 1, DRP-1, DRP1, ULIP-3, Ulip3, Unc-33-like phosphoprotein 3,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodified