ERK 5 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20759-50, ES20759-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008],

Alternate Name: MAPK7; BMK1; ERK5; PRKM7; Mitogen-activated protein kinase 7; MAP kinase 7; MAPK 7; Big MAP kinase 1; BMK-1; Extracellular signal-regulated kinase 5; ERK-5

Source: Rabbit

Applications: WB; IHC; IF

Dilution: WB: 1:1000-2000 IHC:1:200-500

Reactivity: Human; Mouse; Rat

Immunogen: Recombinant Protein of ERK 5

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Observed Band (KD): 89-115kD

Human Gene ID: 5598

Human SWISS Prot NO: Q13164

Subcellular Location: Cytoplasm. Nucleus. Nucleus, PML body. Translocates to the nucleus upon activation.

Research Use Only