IL-20 (D61) Polyclonal Antibody

Catalogue Numbers: BS3464-50, BS3464-100

Sizes: 50µl, 100µl

Alternative Name: Interleukin-20; Short name=IL-20; Cytokine Zcyto10; IL20; ZCYTO10; UNQ852/PRO1801

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9NYY1

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

All Applications: WB: 1:500~1:1000
IHC: 1:50~1:200

Background: IL-20 is a member of the IL-10 family of cytokines that has been shown to be upregulated in psoriatic skin. The receptor for IL-20 (IL-20R) exists as a dimer consisting of IL-20Rα and IL-20Rβ. IL-20R also functions as a receptor for IL-19, IL-24 and IL-26. It is highly expressed in skin, brain and testis. IL-20, IL-20Rα and IL-20Rβ all have higher expression levels in psoriatic lesional (LS) skin than in nonlesional (NL) skin, suggesting a role for these proteins as potential therapeutic targets. IL-20 can induce signal transducer and activator of transcription (Stat) activation through IL-20R.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IL-20 (D61) polyclonal antibody detects endogenous levels of IL-20 protein.

Bioworld Molecular Weight: ~ 28 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of IL20 pAb at 1:500 dilution
Lane 1: A375 whole cell lysate(40ug)
Lane 2: PC3 whole cell lysate(40ug)
Lane 3: MCF-7 whole cell lysate(40ug)
Lane 4: PMVEC whole cell lysate(40ug)
Lane 5: 3T3-L1 whole cell lysate(40ug)

Immunogen: Synthetic peptide, corresponding to amino acids 30-78 of Human IL-20.

Conjugate: Unconjugated

Modification: Unmodified