ACTR-IIA (H59) Polyclonal Antibody

Catalogue Numbers: BS3669-50, BS3669-100

Sizes: 50µl, 100µl

Alternative Name: Activin receptor type-2A; EC=2.7.11.30; Activin receptor type IIA; ACTR-IIA; ACTRIIA; ACVR2A; ACVR2

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P27037

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Members of the transforming growth factor β superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex. Activin has been shown to bind a heteromeric noncovalent complex, which consists of a type I receptor, ACTR-IA (also designated ACVRI and ALK-2) or ACTR-IB (also designated ALK-4 and SKR2), and a type II receptor, ACTR-IIA (ACVR2A) or ACTR-IIB (ACVR2B). Both receptor types are highly expressed in brain. The activin receptor family members are thought to mediate distinct effects on gene expression, cell differentiation and morphogenesis in a dose dependent manner.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ACTR-IIA (H59) polyclonal antibody detects endogenous levels of ACTR-IIA protein.

Bioworld Molecular Weight: ~ 48 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of ACTR-IIA (H59) pAb at 1:500 dilution
Lane 1: AML-12 whole cell lysate(40ug)
Lane 2: C6 whole cell lysate(40ug)
Lane 3: HEK293T whole cell lysate(40ug)
Lane 4: A549 whole cell lysate(40ug)

Immunogen: Synthetic peptide, corresponding to amino acids 30-80 of Human ACTR-IIA.

Conjugate: Unconjugated

Modification: Unmodified