CPM (L113) Polyclonal Antibody

Catalogue Numbers: BS3827-50, BS3827-100

Sizes: 50µl, 100µl

Alternative Name: Carboxypeptidase M; CBPM; CPM; Renal carboxypeptidase; Urinary carboxypeptidase B

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P14384

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Carboxypeptidase M (CPM) is a 443 amino acid protein belonging to the metallo-carboxypeptidase (metallo-CP) family. Localized to the cell membrane, CPM contains hydrophobic regions in the N and C- termini and has six potential asparagine-linked glycosylation sites. Functionally, CPM specifically removes C-terminal basic amino acids (arginine or lysine) from proteins and polypeptides and is believed to play a role in monocyte to macrophage differentiation. CPM is also thought to play an important role in the control of peptide hormone and growth factor activity at the cell surface, as well as in the membrane-localized degradation of extracellular proteins. Three isoforms of this protein exist as a result of alternative splicing events.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CPM (L113) polyclonal antibody detects endogenous levels of CPM protein.

Bioworld Molecular Weight: ~ 51 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of CPM (L113) pAb at 1:500 dilution
Lane 1: Hela whole cell lysate(40ug)
Lane 2: The Uterus tissue lysate of Mouse(40ug)
Lane 3: The Uterus tissue lysate of Rat(40ug)

Immunogen: Synthetic peptide, corresponding to amino acids 80-130 of Human CPM.

Conjugate: Unconjugated

Modification: Unmodified