SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect.

Product information

CAS Number: 1383551-17-4

Molecular Weight: 774.97

Formula: C40H54N8O6S

Chemical Name: tert-butyl 4-{[2-(2-{6-[(2-{[(tert-butoxy)carbonyl](methyl)amino}ethyl)amino]-2-butylpyrimidine-4-amido}phenyl)-[1,3]thiazolo[5,4-b]pyridin-6-yl]methoxy}piperidine-1-carboxylate

Smiles: CN(CCNC1=CC(=NC(CCCC)=N1)C(=O)NC1=CC=CC=C1C1=NC2=CC(COC3CCN(CC3)C(=O)OC(C)(C)C)=CN=C2S1)C(=O)OC(C)(C)C

InChiKey: IXROIZHATNMRLR-UHFFFAOYSA-N

InChi: InChI=1S/C40H54N8O6S/c1-9-10-15-32-43-30(23-33(46-32)41-18-21-47(8)37(50)53-39(2,3)4)34(49)44-29-14-12-11-13-28(29)35-45-31-22-26(24-42-36(31)55-35)25-52-27-16-19-48(20-17-27)38(51)54-40(5,6)7/h11-14,22-24,27H,9-10,15-21,25H2,1-8H3,(H,44,49)(H,41,43,46)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

SRT3657 (30 mg/kg; i.g.; daily; for 6 weeks) activates SIRT1 in CK-p25 mice. SRT3657 treatment prevents synaptic and neuronal loss and effectively rescues against neurodegeneration-driven memory impairments. SRT3657 recapitulates the neuroprotective potential of caloric restriction (CR).

Products are for research use only. Not for human use.