Foxy-5 TFA, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 TFA triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 TFA effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model.

Product information

Molecular Weight: 808.80

Formula: C28H43F3N6O14S2

Chemical Name: (2S, 5S, 8R, 14S)-5-(2-carboxyethyl)-14-((S)-2-formamido-4-(methylthio)butanamido)-2-isobutyl-8-(mercaptomethyl)-4, 7, 10, 13-tetraoxo-3, 6, 9, 12-tetraazahexadecane-1, 16-dioic acid compound with 2, 2, 2-trifluoroacetic acid (1:1)

Smiles: CC(C)C[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CS)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC=O)C(O)=O.OC(=O)C(F)(F)F

InChiKey: CLBGNYFFUUHBLL-HGIJKBOGSA-N

InChi: InChI=1S/C26H42N6O12S2.C2HF3O2/c1-13(2)8-17(26(43)44)32-24(41)15(4-5-20(35)36)30-25(42)18(11-45)29-19(34)10-27-22(39)16(9-21(37)38)31-23(40)14(28-12-33)6-7-46-3;3-2(4,5)1(6)7/h12-18,45H,4-11H2,1-3H3,(H,27,39)(H,28,33)(H,29,34)(H,30,42)(H,31,40)(H,32,41)(H,35,36)(H,37,38)(H,43,44);(H,6,7)/t14-,15-,16-,17-,18-;/m0./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : 20 mg/mL (24.73 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. Foxy-5 reduces the number of colonic cancer stem cells in a xenograft mouse model of human colonic cancer.

Products are for research use only. Not for human use.