gamma-DGG is a competitive AMPA receptor blocker.

Product information

CAS Number: 6729-55-1

Molecular Weight: 204.18

Formula: C7H12N2O5

Chemical Name: (2R)-2-amino-4-[(carboxymethyl)carbamoyl]butanoic acid

Smiles: N[C@H](CCC(=O)NCC(O)=O)C(O)=O

InChiKey: ACIJGUBIMXQCMF-SCSAIBSYSA-N

InChi: InChI=1S/C7H12N2O5/c8-4(7(13)14)1-2-5(10)9-3-6(11)12/h4H,1-3,8H2,(H,9,10)(H,11,12)(H,13,14)/t4-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : ≥ 150 mg/mL (734.65 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

gamma-DGG (γ-DGG), a competitive AMPA receptor blocker that blocks less at higher glutamate concentration. At 200-400 μM, gamma-DGG in the bath reduces the miniature EPSC (mEPSC) amplitude by 26±2% (n=5 synapses), and shifts both the mEPSC amplitude distribution and the cumulative probability curve to the left. gamma-DGG (γ-DGG) is the most effective antagonist of the excitatory post-synaptic potentials (e.p.s.p.s). Its action is reversible and not associated with any change in the passive membrane properties of the granule cells or in the apparent reversal potential of the e.p.s.p. Quantal analysis shows that the reduction in the e.p.s.p. paralleled the decrease in quantal size rather than quantal content, confirming a post-synaptic site of the action of gamma-DGG.

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