Mcl1-IN-8 (Comp8) is a Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. Mcl1-IN-8 (Comp8) exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells.

Product information

CAS Number: 678158-55-9

Molecular Weight: 393.50

Formula: C22H23N3O2S

Chemical Name: (5Z)-5-({[1,1'-biphenyl]-4-yl}methylidene)-2-[4-(2-hydroxyethyl)piperazin-1-yl]-4,5-dihydro-1,3-thiazol-4-one

Smiles: OCCN1CCN(CC1)C1=NC(=O)/C(=C/C2C=CC(=CC=2)C2C=CC=CC=2)/S1

InChiKey: IBEWMFVUBLAYJT-SILNSSARSA-N

InChi: InChI=1S/C22H23N3O2S/c26-15-14-24-10-12-25(13-11-24)22-23-21(27)20(28-22)16-17-6-8-19(9-7-17)18-4-2-1-3-5-18/h1-9,16,26H,10-15H2/b20-16-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 50 mg/mL (127.06 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.