Notch 1 TFA (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types.

Product information

Molecular Weight: 1614.74

Formula: C64H98F3N15O24S3

Chemical Name: L-cysteinyl-L-leucyl-L-aspartyl-L-glutaminyl-L-isoleucylglycyl-L-glutamyl-L-phenylalanyl-L-glutaminyl-L-cysteinyl-L-isoleucyl-L-cysteinyl-L-glutamic acid--2, 2, 2-trifluoroacetic acid (1/1)

Smiles: CC(C)C[C@H](NC(=O)[C@@H](N)CS)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(O)=O)C(O)=O.OC(=O)C(F)(F)F

InChiKey: XGHJSPZBGUXXSZ-LYPPBDAMSA-N

InChi: InChI=1S/C62H97N15O22S3.C2HF3O2/c1-7-30(5)49(76-54(90)36(15-19-44(65)79)69-57(93)40(24-48(85)86)73-55(91)38(22-29(3)4)71-51(87)33(63)26-100)60(96)66-25-45(80)67-34(16-20-46(81)82)52(88)72-39(23-32-12-10-9-11-13-32)56(92)68-35(14-18-43(64)78)53(89)74-42(28-102)59(95)77-50(31(6)8-2)61(97)75-41(27-101)58(94)70-37(62(98)99)17-21-47(83)84;3-2(4,5)1(6)7/h9-13,29-31,33-42,49-50,100-102H,7-8,14-28,63H2,1-6H3,(H2,64,78)(H2,65,79)(H,66,96)(H,67,80)(H,68,92)(H,69,93)(H,70,94)(H,71,87)(H,72,88)(H,73,91)(H,74,89)(H,75,97)(H,76,90)(H,77,95)(H,81,82)(H,83,84)(H,85,86)(H,98,99);(H,6,7)/t30-,31-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,49-,50-;/m0./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Notch 1 is shown to promote mouse luminal prostate cell survival and proliferation through the activation of the prosurvival NF-κB pathway. Down-regulation of Notch 1 and Jagged1 in human prostate cancer cell lines decreases in vitro invasion and cell growth.

Products are for research use only. Not for human use.