Trabectedin D3 (Ecteinascidin 743 D3) is deuterium labeled Trabectedin. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment.

Product information

Molecular Weight: 764.86

Formula: C39H43N3O11S

Chemical Name: [(1R, 2R, 3R, 11S, 12S, 14R, 26R)-5, 6', 12-trihydroxy-6, (7'-d3)-dimethoxy-7, 21, 30-trimethyl-27-oxospiro[17, 19, 28-trioxa-24-thia-13, 30-diazaheptacyclo[12.9.6.13, 11.02, 13.04, 9.015, 23.016, 20]triaconta-4(9), 5, 7, 15, 20, 22-hexaene-26, 1'-3, 4-dihydro-2H-isoquinoline]-22-yl] acetate

Smiles: [2H]C([2H])([2H])OC1=CC2=C(CCN[C@@]32CS[C@H]2[C@@H]4[C@H]5C6=C(C[C@@H]([C@H](O)N4[C@@H](COC3=O)C3=C2C(OC(C)=O)=C(C)C2OCOC=23)N5C)C=C(C)C(OC)=C6O)C=C1O

InChiKey: PKVRCIRHQMSYJX-ZXKUOVGCSA-N

InChi: InChI=1S/C39H43N3O11S/c1-16-9-20-10-22-37(46)42-23-13-50-38(47)39(21-12-25(48-5)24(44)11-19(21)7-8-40-39)14-54-36(30(42)29(41(22)4)26(20)31(45)32(16)49-6)28-27(23)35-34(51-15-52-35)17(2)33(28)53-18(3)43/h9,11-12,22-23,29-30,36-37,40,44-46H,7-8,10,13-15H2,1-6H3/t22-,23-,29+,30-,36+,37-,39+/m0/s1/i5D3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.