NoxA1ds TFA is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50=20 nM). NoxA1ds TFA exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. NoxA1ds TFA inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. NoxA1ds TFA attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro.

Product information

Molecular Weight: 1239.34

Formula: C52H89F3N14O17

Chemical Name: (3S, 6S, 9S, 12S, 18S, 21S, 24S)-24-((S)-2-((S)-1-(L-glutamyl)pyrrolidine-2-carboxamido)-3-methylbutanamido)-6, 12-bis(4-aminobutyl)-3-carbamoyl-18-isobutyl-2, 9, 21-trimethyl-5, 8, 11, 14, 17, 20, 23-heptaoxo-4, 7, 10, 13, 16, 19, 22-heptaazahexacosan-26-oic acid--2, 2, 2-trifluoroacetic acid (1/1)

Smiles: CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(N)=O.OC(=O)C(F)(F)F

InChiKey: GEDTVPJVAIVROF-GZMRMXLRSA-N

InChi: InChI=1S/C50H88N14O15.C2HF3O2/c1-25(2)22-33(44(73)55-24-36(65)58-31(14-9-11-19-51)45(74)56-28(7)42(71)59-32(15-10-12-20-52)46(75)62-39(26(3)4)41(54)70)60-43(72)29(8)57-47(76)34(23-38(68)69)61-49(78)40(27(5)6)63-48(77)35-16-13-21-64(35)50(79)30(53)17-18-37(66)67;3-2(4,5)1(6)7/h25-35,39-40H,9-24,51-53H2,1-8H3,(H2,54,70)(H,55,73)(H,56,74)(H,57,76)(H,58,65)(H,59,71)(H,60,72)(H,61,78)(H,62,75)(H,63,77)(H,66,67)(H,68,69);(H,6,7)/t28-,29-,30-,31-,32-,33-,34-,35-,39-,40-;/m0./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.