AS1269574 is a potent, orally available GPR119 agonist, with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic β-cells only under high-glucose conditions. AS1269574 has the potential for the research of type 2 diabetes.

Product information

CAS Number: 330981-72-1

Molecular Weight: 308.17

Formula: C13H14BrN3O

Chemical Name: 2-{[2-(4-bromophenyl)-6-methylpyrimidin-4-yl]amino}ethan-1-ol

Smiles: CC1=CC(NCCO)=NC(=N1)C1C=CC(Br)=CC=1

InChiKey: DUKPGOOUJNUIOI-UHFFFAOYSA-N

InChi: InChI=1S/C13H14BrN3O/c1-9-8-12(15-6-7-18)17-13(16-9)10-2-4-11(14)5-3-10/h2-5,8,18H,6-7H2,1H3,(H,15,16,17)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (811.24 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

AS1269574 sgnificantly reduced the blood glucose AUC after 2 h (AUC0-2h) of administration.

Products are for research use only. Not for human use.