Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Furin inhibitor I is a selective, irreversible, and cell-permeable competitive inhibitor of proprotein convertases, including furin/SPC1 (Ki = ~1 nM), SPC2/PC2 (Ki = 0.36 nM), SPC3/PC1/PC3 (Ki = 2.0 nM), SPC4/PACE4 (Ki = 3.6 nM), SPC6/PC5/PC6, and SPC7/LPC/PC7/PC8 (Ki = 0.12 nM)., Because furin activates viral glycoproteins, this inhibitor is a useful antiviral agent. In addition, it inhibits furin-dependent pro-MMP-2 activation in mononuclear inflammatory cells. Reference: . Angliker, H., Wikstrom, P., Shaw, E., et al. The synthesis of inhibitors for processing proteinases and their action on the Kex2 proteinase of yeast. Biochemistry Journal 293(1), 75-81 (1993). . Fugère, M., Limperis, P.C., Beaulieu-Audy, V., et al. Inhibitory potency and specificity of subtilase-like Pro-protein convertase (SPC) prodomains. The Journal of Biological Chemisty 277(10), 7648-7656 (2002). . Wanyiri, J.W., O'Connor, R., Allison, G., et al. Proteolytic processing of the Cryptosporidium glycoprotein gp40/15 by human furin and by a parasite-derived furin-like protease activity. Infection and Immunity 75(1), 184-192 (2007). . Stawowy, P., Meyborg, H., Stibenz, D., et al. Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis. Circulation 111(21), 2820-2827 (2005).

Product information

CAS Number: 150113-99-8

Molecular Weight: 744.41

Formula: C34H66ClN11O5

Chemical Name: (2S)-2-[(2R)-6-amino-2-[(2R)-2-[(2S)-5-[(diaminomethylidene)amino]-2-undecanamidopentanamido]-3-methylbutanamido]hexanamido]-5-[(diaminomethylidene)amino]pentanoyl chloride

Smiles: CC(C)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCCCCCCCCC)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)Cl

InChiKey: BVMLNMPANYZIGJ-WDTRASESSA-N

InChi: InChI=1S/C34H66ClN11O5/c1-4-5-6-7-8-9-10-11-19-27(47)43-25(18-15-22-42-34(39)40)31(50)46-28(23(2)3)32(51)45-26(16-12-13-20-36)30(49)44-24(29(35)48)17-14-21-41-33(37)38/h23-26,28H,4-22,36H2,1-3H3,(H,43,47)(H,44,49)(H,45,51)(H,46,50)(H4,37,38,41)(H4,39,40,42)/t24-,25-,26+,28+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.