Norswertianin, a xanthone compound, serves as a powerful anti-glioma compound. Norswertianin induces GBM cells differentiation through oxidative stress and Akt/mTOR dependent autophagy.

Product information

CAS Number: 22172-15-2

Molecular Weight: 260.20

Formula: C13H8O6

Chemical Name: 1,2,6,8-tetrahydroxy-9H-xanthen-9-one

Smiles: OC1C=C(O)C=C2OC3=CC=C(O)C(O)=C3C(=O)C=12

InChiKey: RVOUOPDWADMVBA-UHFFFAOYSA-N

InChi: InChI=1S/C13H8O6/c14-5-3-7(16)10-9(4-5)19-8-2-1-6(15)12(17)11(8)13(10)18/h1-4,14-17H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Norswertianin (12.5-50 µM; 48 hours) stimulats expression of GFAP and β-tubulin in U251 cells. Norswertianin (40 µM; 48 hours) causes the appearance of elongated processes in U251 cells, associated with G2/M cell cycle arrest. Norswertianin (40 µM; 48 hours) exhibits an increase in intracellular acidification and LC3 conversion.

Products are for research use only. Not for human use.