Multitarget AD inhibitor-1 is a selective and reversible butyrylcholinesterase (BuChE) inhibitor with IC50s of 7.22 μM and 1.55 μM for hBuChE and eqBuChE (BuChE from equine serum), respectively. Multitarget AD inhibitor-1 inhibits β-secretase (IC50hBACE-1=41.60 μM), amyloid β aggregation (IC50Aβ=3.09 μM), tau aggregation. Multitarget AD inhibitor-1, a diphenylpropylamine derivative, has the potential for multifunctional disease-modifying anti-Alzheimer’s research.

Product information

CAS Number: 2205015-77-4

Molecular Weight: 430.62

Formula: C29H38N2O

Chemical Name: (3-{[(3-tert-butylphenyl)methyl]amino}-2-hydroxypropyl)(3,3-diphenylpropyl)amine

Smiles: CC(C)(C)C1=CC=CC(CNCC(O)CNCCC(C2=CC=CC=C2)C2=CC=CC=C2)=C1

InChiKey: QEVPSMYJQDNACG-UHFFFAOYSA-N

InChi: InChI=1S/C29H38N2O/c1-29(2,3)26-16-10-11-23(19-26)20-31-22-27(32)21-30-18-17-28(24-12-6-4-7-13-24)25-14-8-5-9-15-25/h4-16,19,27-28,30-32H,17-18,20-22H2,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Multitarget AD inhibitor-1 (compound 10) selectively inhibits BuChE from equine serum (eqBuChE) and hBuChE over AChE from electric eel (eeAChE; 21.78% at 10 μM). Multitarget AD inhibitor-1 (10 μM) inhibits full-length tau aggregation with 44.4%.

Products are for research use only. Not for human use.