C-176 is a strong and covalent mouse STING inhibitor.

Product information

CAS Number: 314054-00-7

Molecular Weight: 358.09

Formula: C11H7IN2O4

Chemical Name: N-(4-iodophenyl)-5-nitrofuran-2-carboxamide

Smiles: [O-][N+](=O)C1=CC=C(O1)C(=O)NC1C=CC(I)=CC=1

InChiKey: JBIKQXOZLBLMKI-UHFFFAOYSA-N

InChi: InChI=1S/C11H7IN2O4/c12-7-1-3-8(4-2-7)13-11(15)9-5-6-10(18-9)14(16)17/h1-6H,(H,13,15)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 62.5 mg/mL (174.54 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6.

In Vivo:

C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity. C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1−/− mice. C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1−/− mice.

Products are for research use only. Not for human use.