Boc-NH-PEG6-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 1262991-52-5

Molecular Weight: 419.51

Formula: C20H37NO8

Chemical Name: tert-butyl N-(3,6,9,12,15,18-hexaoxahenicos-20-yn-1-yl)carbamate

Smiles: CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCOCC#C

InChiKey: DQBRWZSCEDQMRF-UHFFFAOYSA-N

InChi: InChI=1S/C20H37NO8/c1-5-7-23-9-11-25-13-15-27-17-18-28-16-14-26-12-10-24-8-6-21-19(22)29-20(2,3)4/h1H,6-18H2,2-4H3,(H,21,22)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.