GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. GLPG-3221 can be uesd for the treatment of cystic fibrosis.

Product information

CAS Number: 2222264-64-2

Molecular Weight: 578.62

Formula: C30H37F3N2O6

Chemical Name: (2S,3R,4S,5S)-3-tert-butyl-4-{[2-methoxy-5-(trifluoromethyl)pyridin-3-yl]methoxy}-5-(2-methylphenyl)-1-[(2S)-oxane-2-carbonyl]pyrrolidine-2-carboxylic acid

Smiles: CC(C)(C)[C@@H]1[C@@H](C(O)=O)N([C@H]([C@H]1OCC1=CC(=CN=C1OC)C(F)(F)F)C1=CC=CC=C1C)C(=O)[C@@H]1CCCCO1

InChiKey: YFEYDNAKCSOOOG-YCXOGWGTSA-N

InChi: InChI=1S/C30H37F3N2O6/c1-17-10-6-7-11-20(17)23-25(41-16-18-14-19(30(31,32)33)15-34-26(18)39-5)22(29(2,3)4)24(28(37)38)35(23)27(36)21-12-8-9-13-40-21/h6-7,10-11,14-15,21-25H,8-9,12-13,16H2,1-5H3,(H,37,38)/t21-,22+,23-,24-,25-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

GLPG-3221 (1 mg/kg; i.v.) treatment shows the Cl and t1/2 are 0.13 L/h/kg and 3 hours, respectively. GLPG-3221 (1 mg/kg; p.o.)treatment shows the F% value is 53%.

Products are for research use only. Not for human use.