PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R (IC50=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo.

Product information

CAS Number: 667430-81-1

Molecular Weight: 1180.40

Formula: C59H85N15O11

Chemical Name: (Z)-N-[(3S,6S,9S,12S,20S,25aS)-3-benzyl-6-(3-carbamimidamidopropyl)-1,4,7,10,18-pentahydroxy-12-[(2S)-2-[(Z)-[(1S)-1-(C-hydroxycarbonimidoyl)-2-methylpropyl]-C-hydroxycarbonimidoyl]pyrrolidine-1-carbonyl]-9-[(1H-indol-3-yl)methyl]-21-oxo-3H,6H,9H,12H,13H,14H,15H,16H,19H,20H,21H,23H,24H,25H,25aH-pyrrolo[2,1-l]1,4,7,10,13,18-hexaazacyclotricosan-20-yl]-2-[(Z)-(1-hydroxyethylidene)amino]hexanimidic acid

Smiles: C/C(/O)=N/C(CCCC)/C(/O)=N/[C@H]1CC(O)=NCCCC[C@H](N=C(O)[C@H](CC2=CNC3=CC=CC=C23)N=C(O)[C@H](CCCNC(N)=N)N=C(O)[C@H](CC2C=CC=CC=2)N=C(O)[C@@H]2CCCN2C1=O)C(=O)N1CCC[C@H]1/C(/O)=N/[C@@H](C(C)C)C(=N)O |c:15,22,38,49,t:61|

InChiKey: WOFDJLFPEWSAPJ-RVBGBMFGSA-N

InChi: InChI=1S/C59H85N15O11/c1-5-6-20-40(66-35(4)75)51(78)71-45-32-48(76)63-26-13-12-22-42(57(84)73-28-16-25-47(73)56(83)72-49(34(2)3)50(60)77)68-54(81)44(31-37-33-65-39-21-11-10-19-38(37)39)69-52(79)41(23-14-27-64-59(61)62)67-53(80)43(30-36-17-8-7-9-18-36)70-55(82)46-24-15-29-74(46)58(45)85/h7-11,17-19,21,33-34,40-47,49,65H,5-6,12-16,20,22-32H2,1-4H3,(H2,60,77)(H,63,76)(H,66,75)(H,67,80)(H,68,81)(H,69,79)(H,70,82)(H,71,78)(H,72,83)(H4,61,62,64)/t40?,41-,42-,43-,44-,45-,46-,47-,49-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

PG-931 (intravenous injection; 13-108 nmol/kg; single dose) produces a dose-dependent restoration of cardiovascular and respiratory functions, and improved survival in Wistar rats with haemorrhagic shock.

Products are for research use only. Not for human use.