GR 94800 is a potent and selective NK2 receptor peptide antagonist, with pKB values of 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors, respectively.

Product information

CAS Number: 141636-65-9

Molecular Weight: 904.06

Formula: C49H61N9O8

Chemical Name: (2S)-2-{[(2S)-1-[(2R)-1-[(2S)-2-[(2R)-3-(1H-indol-3-yl)-2-[(2S)-2-[(2S)-2-(phenylformamido)propanamido]propanamido]propanamido]-3-phenylpropanoyl]pyrrolidine-2-carbonyl]pyrrolidin-2-yl]formamido}hexanamide

Smiles: CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@@H](CC1=CNC2=CC=CC=C12)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)C1C=CC=CC=1)C(N)=O

InChiKey: CWEISCOCKRHHOU-UJYVDGJVSA-N

InChi: InChI=1S/C49H61N9O8/c1-4-5-21-37(42(50)59)54-47(64)40-23-14-25-57(40)49(66)41-24-15-26-58(41)48(65)39(27-32-16-8-6-9-17-32)56-46(63)38(28-34-29-51-36-22-13-12-20-35(34)36)55-44(61)31(3)52-43(60)30(2)53-45(62)33-18-10-7-11-19-33/h6-13,16-20,22,29-31,37-41,51H,4-5,14-15,21,23-28H2,1-3H3,(H2,50,59)(H,52,60)(H,53,62)(H,54,64)(H,55,61)(H,56,63)/t30-,31-,37-,38+,39-,40-,41+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Responses to EFS (15 Hz) were significantly reduced by the NK2 receptor antagonist GR 94800 (1 μM) either alone or in combination with the NK1 antagonist (1 μM).

Products are for research use only. Not for human use.