PCNA Mouse mAb

Sizes: 50μL, 100μL

Catalogue Numbers: EM1030-50, EM1030-100

Citations, Manuals and MSDS Available upon request.

Background: PCNA is a marker for cells in early G1 phase and S phase of the cell cycle. It is found in the nucleus and is a cofactor of DNA polymerase delta. PCNA acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, PCNA is ubiquitinated and is involved in the RAD6 dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for PCNA. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.

Source: Mouse

Applications: WB, IHC

Dilution: WB 1:5, 000 IHC 1:200

Reactivity: Human, Rat, Mouse

Immunogen: Synthetic Peptide

Storage and Stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality: Monoclonal

Isotype: IgG1

Concentration: 1mg/mL

Observed Band (KD): 29kDa

Human Gene ID: 5111

Human SWISS Prot NO: P12004

Subcellular Location: Nucleus

Research Use Only