WWTR1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES10647-50, ES10647-100

Citations, Manuals and MSDS Available upon request.

Background: domain:Binds to transcription factors via its WW domain., domain:The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes., function:Functions as a transcriptional coactivator., PTM:Phosphorylated. Phosphorylation results in the inhibition of transcriptional coactivation through YWHAZ-mediated nuclear export., similarity:Contains 1 WW domain., subcellular location:Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ., subunit:Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP., tissue specificity:Highly expressed in kidney, heart, placenta and lung.,

Source: Rabbit

Applications: WB; ELISA

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Reactivity: Human; Mouse

Immunogen: Synthesized peptide derived from part region of human protein

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 44kD

Human Gene ID: 25937

Human SWISS Prot NO: Q9GZV5

Subcellular Location: Nucleus. Cytoplasm. Cell membrane. Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies (By similarity). When phosphorylated, is retained in the cytoplasm by YWHAZ (By similarity). Can be retained in the nucleus by MED15 (PubMed:18568018). Localized in the cytoplasm in areas of epithelial cell high density (PubMed:21145499). At blastocyst stage expressed in the nucleus in trophectodermal cells, however expressed in the cytoplasm in the inner cell mass (By similarity).

Research Use Only