Mu opioid receptor antagonist 3 (compound 26) is a potent and selective μ opioid receptor (MOR) antagonist with a Ki of 0.24 nM and an EC50 of 0.54 nM. Mu opioid receptor antagonist 3 has remarkable CNS antagonism against morphine, and precipitated fewer withdrawal symptoms than Naloxone. Mu opioid receptor antagonist 3 can be used for researching opioid use disorders (OUD)[1].

Product information

Molecular Weight: 452.57

Formula: C25H28N2O4S

Chemical Name: N-[(1S, 5R, 13R, 14S, 17S)-4-(cyclopropylmethyl)-10, 17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0, .0, .0, ]octadeca-7(18), 8, 10-trien-14-yl]thiophene-2-carboxamide

Smiles: O[C@]12CC[C@H](NC(=O)C3=CC=CS3)[C@@H]3OC4=C5C(C[C@H]1N(CC1CC1)CC[C@]253)=CC=C4O

InChiKey: QWAXZSMUYRTIIN-SVWSUJCXSA-N

InChi: InChI=1S/C25H28N2O4S/c28-17-6-5-15-12-19-25(30)8-7-16(26-23(29)18-2-1-11-32-18)22-24(25,20(15)21(17)31-22)9-10-27(19)13-14-3-4-14/h1-2,5-6,11,14,16,19,22,28,30H,3-4,7-10,12-13H2,(H,26,29)/t16-,19+,22-,24-,25+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Pagare PP, et al. Design, Synthesis, and Biological Evaluation of NAP Isosteres: A Switch from Peripheral to Central Nervous System Acting Mu-Opioid Receptor Antagonists. J Med Chem. 2022;65(6):5095-5112.

Products are for research use only. Not for human use.