PD-1-IN-24 (compound 1) is an orally active PD-1 inhibitor.

Product information

CAS Number: 2360909-50-6

Molecular Weight: 469.50

Formula: C27H26F3NO3

Chemical Name: (2S)-3-hydroxy-2-methyl-2-[({3-[(E)-2-{2-methyl-[1,1'-biphenyl]-3-yl}ethenyl]-4-(trifluoromethyl)phenyl}methyl)amino]propanoic acid

Smiles: C[C@@](CO)(NCC1=CC(/C=C/C2=CC=CC(C3C=CC=CC=3)=C2C)=C(C=C1)C(F)(F)F)C(O)=O

InChiKey: ITARRJJJADSSAW-JYSHFMIGSA-N

InChi: InChI=1S/C27H26F3NO3/c1-18-20(9-6-10-23(18)21-7-4-3-5-8-21)12-13-22-15-19(11-14-24(22)27(28,29)30)16-31-26(2,17-32)25(33)34/h3-15,31-32H,16-17H2,1-2H3,(H,33,34)/b13-12+/t26-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

PD-1-IN-24 (compound 1, 15mg/kg, PO, BID) exhibits TGI(%) of 19.96% in the subcutaneous 4T1 murine breast cancer model in BALB/c mice. PD-1-IN-24 (compound 1, 15mg/kg, PO, BID) dose-dependently inhibits tumor growth in the Bl6F10 models with TGI% of 35.59% (30 mg/kg), 38.87% (60 mg/kg) and 47.35% (120 mg/kg), respectively.

Products are for research use only. Not for human use.