Rigosertib (ON-01910,Estybon) is a potent, specific PLK1 inhibitor with IC50 value of 9nM. Rigosertib strongly inhibited the proliferation of cancer cell lines, with observed IC50 values in the nanomolar range for both HeLa (115 nM) and C33A (45 nM) cells. In contrast, rigosertib had a minimal effect on normal cell lines, BJ and Ect1/E6E7 (IC50 > 0.1 mM) HeLa and C33A cells demonstrated a complete (>95%) G2/M arrest at concentrations of rigosertib >0.5 μM, whereas at <0.2 μM no clear perturbation of the cell cycle was evident. Normal cells were less affected by rigosertib . Rigosertib has been reported to be a more potent radiosensitizer than cisplatin in vivo .

Product information

CAS Number: 1225497-78-8

Molecular Weight: 473.47

Formula: C21H24NNaO8S

Chemical Name: sodium 2-[(2-methoxy-5-{[2-(2,4,6-trimethoxyphenyl)ethenesulfonyl]methyl}phenyl)amino]acetate

Smiles: [Na+].COC1C=C(OC)C(C=CS(=O)(=O)CC2C=CC(OC)=C(C=2)NCC([O-])=O)=C(C=1)OC

InChiKey: VLQLUZFVFXYXQE-USRGLUTNSA-M

InChi: InChI=1S/C21H25NO8S.Na/c1-27-15-10-19(29-3)16(20(11-15)30-4)7-8-31(25,26)13-14-5-6-18(28-2)17(9-14)22-12-21(23)24;/h5-11,22H,12-13H2,1-4H3,(H,23,24);/q;+1/p-1/b8-7+;

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.