CBL Polyclonal Antibody Sizes: 60μL, 120μL, 200μL Catalogue Numbers: E-AB-91759-60, E-AB-91759-120, E-AB-91759-200 Citations, Manuals and MSDS Available upon request. Abbreviation: CBL Target Synonym: C-CBL; CBL2; FRA11B; NSLL; RNF55; CBL; c-Cbl Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Signal Transduction Conjugation: Unconjugated Host: Rabbit Species Reactivity: Human, Mouse Application: WB Isotype: IgG Clonality: Polyclonal UNIProt ID: P22681 Background: This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016] Concentration: 1mg/mL Immunogen: A synthetic peptide of Human CBL Buffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3. Purification Method: Affinity purification Dilution: WB 1:500-1:2000 Calculated MW: 99kDa Observed MW: 120kDa Storage: -20°C/One year. Avoid freeze / thaw cycles. Shipping: Ice bag Research Use Only