MeCP2 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20671-50, ES20671-100

Citations, Manuals and MSDS Available upon request.

Background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isofor

Alternate Name: Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)

Source: Rabbit

Applications: WB

Dilution: WB: 1:2000

Reactivity: Human

Immunogen: Synthetic Peptide of MeCP2 AA range: 313-363

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Observed Band (KD): 53kD

Human Gene ID: 4204

Human SWISS Prot NO: P51608

Subcellular Location: Nucleus. Colocalized with methyl-CpG in the genome. Colocalized with TBL1X to the heterochromatin foci.

Research Use Only