AIRE-1 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA21739-50, RA21739-100

Citations, Manuals and MSDS Available upon request.

Background: autoimmune regulator (AIRE) Homo sapiens This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED) . [provided by RefSeq, Jun 2012],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Alternative Names: AIRE; APECED; Autoimmune regulator; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; APECED protein

Applications: WB; IF/ICC; ELISA

Species Cross-Reactivity: Human; Mouse

GeneID (Human): 326

Protein MW (KDa): 60

SWISS: O43918

Source: Rabbit

Research Use Only