Desmin Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90406-50, BS90406-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P17661

Host: Rabbit

Reactivity: Human, Mouse, zebrafish

Applications: WB, ICC IHC

All Applications: WB:1:1,000-1:2,000
ICC:1:200
IHC:1:200

Background: Desmin is one of the earliest protein markers for muscle tissue in embryogenesis as it is detected in the somites. Although it is present early in the development of muscle cells, it is only expressed at low levels, and increases as the cell nears terminal differentiation. Desmin is also important in muscle cell architecture and structure since it connects many components of the cytoplasm. Finally, desmin may be important in mitochondria function. Desmin-related myopathy (DRM or Desminopathy) is a subgroup of the myofibrillar myopathy diseases and is the result of a mutation in the gene that codes for desmin which prevents it from forming protein filaments, instead forming aggregates of desmin and other proteins throughout the cell. Recently, mutations were identified in patients suffered by an arrhythmogenic right ventricular cardiomyopathy (ARVC).

Purification and Purity: Peptide affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Desmin polyclonal antibody detects endogenous levels of Desmin protein.

Bioworld Molecular Weight: 53 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Desmin on different cell lysates using anti-Desmin antibody at 1/2000 dilution.
Positive control:
Lane 1: Human skeletal muscle tissue
Lane 2: Mouse heart tissue
Lane 3: Human heart tissue, ICC staining of Desmin in HepG2 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: DESM, CMD1I, CSM1, CSM2, DES, DESM, Desmin, FLJ12025, FLJ39719, FLJ41013, FLJ41793, Intermediate filament protein, OTTHUMP00000064865,

Immunogen: peptide

Conjugate: Unconjugated

Modification: Unmodified