SENP1 (D2) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS1469-50, BS1469-100

Sizes: 50µl, 100µl

Swiss-Prot: Q9P0U3

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

Background: SUMO (small ubiquitin-related modifier), a member of the ubiquitin-like protein family, regulates diverse cellular functions of a variety of target proteins including transcription, DNA repair, nucleocytoplasmic trafficking and chromosome segregation. SUMO precursor proteins undergo cleavage of the residues after the “GG” region by SUMO-specific proteases in maturation. This cleavage of the precursor is a prerequisite for subsequent sumoylation. The sentrin-specific (or SUMO-specific) protease (SENP) proteins belong to the peptidase C48 family and include SENP1-3 and SENP5-8. SENP1, SENP2 and SENP3 degrade UBL1 and SMT3H2 conjugates and subsequently release the monomers from sumoylated substrates.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: SENP1 (D2) polyclonal antibody detects endogenous levels of SENP1 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of SENP1 (D2) polyclonal antibody at 1:500 dilution
Lane 1: Hela whole cell lysate (40ug)
Lane 2: The Testis cells tissue lysate of Rat (40ug)
Lane 3: The Testis cells tissue lysate of Mouse (40ug), Immunohistochemistry (IHC) analyzes of SENP1 (D2) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Bioworld Molecular Weight: ~ 73 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Sentrin-specific protease 1; Sentrin/SUMO-specific protease SENP1; SEN1

Immunogen: Synthetic peptide, corresponding to the N-terminual of Human SENP1.

Conjugate: Unconjugated

Modification: Unmodified