LY2922470 is a potent, selective and orally available agonist of the G protein-coupled receptor 40 (GPR40), with EC50s of 7 nM, 1 nM and 3 nM for human GPR40, mouse GPR40 and rat GPR40, respectively. LY2922470 reduces glucose levels along with significant increases in insulin and GLP-1, is potential for the treatment of type 2 diabetes mellitus (T2DM).

Product information

CAS Number: 1423018-12-5

Molecular Weight: 475.60

Formula: C28H29NO4S

Chemical Name: (3S)-3-[4-({5-[(8-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)methyl]thiophen-2-yl}methoxy)phenyl]hex-4-ynoic acid

Smiles: COC1C=CC=C2CCCN(CC3=CC=C(COC4C=CC(=CC=4)[C@H](CC(O)=O)C#CC)S3)C2=1

InChiKey: VJVDLRVFJTVWEO-QFIPXVFZSA-N

InChi: InChI=1S/C28H29NO4S/c1-3-6-22(17-27(30)31)20-10-12-23(13-11-20)33-19-25-15-14-24(34-25)18-29-16-5-8-21-7-4-9-26(32-2)28(21)29/h4,7,9-15,22H,5,8,16-19H2,1-2H3,(H,30,31)/t22-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 125 mg/mL (262.83 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.