DDR2 Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA20720-50, RA20720-100 Citations, Manuals and MSDS Available upon request. Background: discoidin domain receptor tyrosine kinase 2 (DDR2) Homo sapiens Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcr Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: IHC-p 1:50-200, IF1：500 ELISA 1:10000-20000 Alternative Names: Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b) Applications: IF/ICC; IHC-p; ELISA Species Cross-Reactivity: Human; Mouse GeneID (Human): 4921 SWISS: Q16832 Source: Rabbit Research Use Only