β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA, the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 TFA forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution).

Product information

Molecular Weight: 1517.62

Formula: C61H103F3N16O23S

Chemical Name: (2S, 5S, 11S, 14S, 17S, 23S, 26S, 29S, 35S, 38S, 41S)-41-amino-26-(2-amino-2-oxoethyl)-23-(4-aminobutyl)-11, 14-di-sec-butyl-38-(carboxymethyl)-29-(hydroxymethyl)-5-isobutyl-35-isopropyl-17-methyl-2-(2-(methylthio)ethyl)-4, 7, 10, 13, 16, 19, 22, 25, 28, 31, 34, 37, 40-tridecaoxo-3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33, 36, 39-tridecaazatetratetracontane-1, 44-dioic acid compound with 2, 2, 2-trifluoroacetic acid (1:1)

Smiles: CC(C)C[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CCC(O)=O)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](CCSC)C(O)=O.OC(=O)C(F)(F)F

InChiKey: KCXLLHVWIBOFKL-KPRPSXLASA-N

InChi: InChI=1S/C59H102N16O21S.C2HF3O2/c1-11-30(7)47(57(93)65-25-42(79)67-36(21-28(3)4)52(88)70-35(59(95)96)18-20-97-10)75-58(94)48(31(8)12-2)74-49(85)32(9)66-41(78)24-63-51(87)34(15-13-14-19-60)69-53(89)37(22-40(62)77)72-55(91)39(27-76)68-43(80)26-64-56(92)46(29(5)6)73-54(90)38(23-45(83)84)71-50(86)33(61)16-17-44(81)82;3-2(4,5)1(6)7/h28-39,46-48,76H,11-27,60-61H2,1-10H3,(H2,62,77)(H,63,87)(H,64,92)(H,65,93)(H,66,78)(H,67,79)(H,68,80)(H,69,89)(H,70,88)(H,71,86)(H,72,91)(H,73,90)(H,74,85)(H,75,94)(H,81,82)(H,83,84)(H,95,96);(H,6,7)/t30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,46-,47-,48-;/m0./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA shows significant cytotoxicity on the rat hippocampal neurons at 40 μg/mL, but exhibits no cytotoxic effect on the glial cells.

Products are for research use only. Not for human use.