SAR629 is a potent monoglyceride lipase (MGL) covalent inhibitor. SAR629 also inhibits 2-Arachidonoylglycerol (2-AG) degradation.

Product information

CAS Number: 1221418-42-3

Molecular Weight: 383.39

Formula: C20H19F2N5O

Chemical Name: 1-[bis(4-fluorophenyl)methyl]-4-(1H-1,2,4-triazole-1-carbonyl)piperazine

Smiles: O=C(N1C=NC=N1)N1CCN(CC1)C(C1C=CC(F)=CC=1)C1C=CC(F)=CC=1

InChiKey: UIOVHJYJUUSVIG-UHFFFAOYSA-N

InChi: InChI=1S/C20H19F2N5O/c21-17-5-1-15(2-6-17)19(16-3-7-18(22)8-4-16)25-9-11-26(12-10-25)20(28)27-14-23-13-24-27/h1-8,13-14,19H,9-12H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

SAR629 is a potent dual inhibitory action on MAGL and fatty acid amide hydrolase (FAAH). SAR629 inhibits rodent monoglyceride lipase (MGL) activity at subnanomolar potencies (IC50 values of 1.1 nM and 219 pM in rat and mouse brain membranes, respectively).

Products are for research use only. Not for human use.