DD 03-171, CAS No. 2366132-45-6, is a novel degrader of bruton's tyrosine kinase (btk), potently suppressing signaling and proliferation in cancer cells, reducing tumor burden and extends survival in lymphoma pdx models.

Product information

CAS Number: 2366132-45-6

Molecular Weight: 991.14

Formula: C55H62N10O8

Synonym:

DD 03-171

DD 03171

DD03171

DD-03171

DD-03-171

DD03-171

Chemical Name: 4-(tert-Butyl)-N-(3-(6-((4-(4-(6-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)hexyl)piperazine-1-carbonyl)phenyl)amino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)benzamide

Smiles: CN1C=C(N=C(NC2C=CC(=CC=2)C(=O)N2CCN(CC2)CCCCCCNC(=O)CNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1=O)C1=CC=CC(NC(=O)C2C=CC(=CC=2)C(C)(C)C)=C1C

InChiKey: QBPVFCNYKUENHU-UHFFFAOYSA-N

InChi: InChI=1S/C55H62N10O8/c1-34-39(12-10-14-41(34)60-49(68)35-16-20-37(21-17-35)55(2,3)4)43-33-62(5)54(73)48(59-43)58-38-22-18-36(19-23-38)51(70)64-30-28-63(29-31-64)27-9-7-6-8-26-56-46(67)32-57-42-15-11-13-40-47(42)53(72)65(52(40)71)44-24-25-45(66)61-50(44)69/h10-23,33,44,57H,6-9,24-32H2,1-5H3,(H,56,67)(H,58,59)(H,60,68)(H,61,66,69)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

References:

1. Dobrovolsky D, Wang ES, Morrow S, Leahy C, Faust T, Nowak RP, Donovan KA, Yang G, Li Z, Fischer ES, Treon SP, Weinstock DM, Gray NS. Bruton tyrosine kinase degradation as a therapeutic strategy for cancer. Blood. 2019 Feb 28;133(9):952-961. doi: 10.1182/blood-2018-07-862953. Epub 2018 Dec 13. PubMed PMID: 30545835; PubMed Central PMCID: PMC6396177.

Products are for research use only. Not for human use.