Methyltetrazine-amido-PEG7-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 2112731-46-9

Molecular Weight: 606.67

Formula: C27H42N8O8

Chemical Name: 1-azido-N-{[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}-3,6,9,12,15,18,21-heptaoxatetracosan-24-amide

Smiles: CC1=NN=C(N=N1)C1=CC=C(CNC(=O)CCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])C=C1

InChiKey: PQDMYSBOSSHIPG-UHFFFAOYSA-N

InChi: InChI=1S/C27H42N8O8/c1-23-31-33-27(34-32-23)25-4-2-24(3-5-25)22-29-26(36)6-8-37-10-12-39-14-16-41-18-20-43-21-19-42-17-15-40-13-11-38-9-7-30-35-28/h2-5H,6-22H2,1H3,(H,29,36)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.