FosB Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90524-50, BS90524-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P53539(Human) P13346(Mouse) EntrezGene:100360880(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ICC/IF, IHC, IP,

All Applications: WB:1:1,000
ICC:1:50-1:200
IHC:1:50-1:200

Background: The v-Fos oncogene was initially identified as the transforming gene of two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phosphoprotein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA TPA response elements (TREs), c-Fos proteins are only active as heterodimers with members of the Jun gene family. Murine Fos B encodes a nuclear protein of 338 amino acids which has 70% homology with c-Fos, exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B which bind to TRE DNA response elements. Functional homologs of c-Fos and Fos B include Fra-1 and Fra-2 genes.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: FosB polyclonal antibody detects endogenous levels of FosB protein.

Bioworld Molecular Weight: 48 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of FosB on human liver lysates using anti-FosB antibody at 1/1,000 dilution., Immunohistochemical analysis of paraffin-embedded rat spleen tissue using anti-FosB antibody. Counter stained with hematoxylin.

Alternative Name: FOSB, Activator protein 1, AP 1, DKFZp686C0818, FBJ murine osteosarcoma viral oncogene homolog B, fosB, FOSB, G0/G1 switch regulatory protein 3, G0S3, GOS 3, GOS B, GOS3, GOSB, MGC42291, Oncogene FOS B, Oncogene FOSB, Protein fos B, Protein fosB,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified