Rac-Nedisertib (Rac-M3814) is a racemate of Nedisertib, a potent DNA-PK inhibitor, with an IC50 of <3 nM.DNA-PK|<3 nM (IC50) Rac-Nedisertib (Compound 137) potently inhibits DNA-PK, with an IC50 of <3 nM for DNA-PK, 0.5-5 μM for cellular pDNA-PK and 15-25 μM for KV11.1 (hERG, human ether a-go-go related gene) ).. . Thomas Fuchss, et al. Arylchinazoline. WO2014183850A1.

Product information

CAS Number: 1637542-34-7

Molecular Weight: 481.91

Formula: C24H21ClFN5O3

Chemical Name: {2-chloro-4-fluoro-5-[7-(morpholin-4-yl)quinazolin-4-yl]phenyl}(6-methoxypyridazin-3-yl)methanol

Smiles: COC1C=CC(=NN=1)C(O)C1C=C(C(F)=CC=1Cl)C1N=CN=C2C=C(C=CC=12)N1CCOCC1

InChiKey: MOWXJLUYGFNTAL-UHFFFAOYSA-N

InChi: InChI=1S/C24H21ClFN5O3/c1-33-22-5-4-20(29-30-22)24(32)16-11-17(19(26)12-18(16)25)23-15-3-2-14(10-21(15)27-13-28-23)31-6-8-34-9-7-31/h2-5,10-13,24,32H,6-9H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.