Calumenin (C-terminus) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB0120-50, MB0120-100

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O43852

Host: Mouse IgG1

Reactivity: Human, Mouse

Applications: WB

All Applications: WB:1:1000

Background: Caluminin is a 315 amino acid Ca2+-binding member of the CREC, EF-hand protein family. Calumenin is a secreted protein t hat contains six Ca2+-binding (EF-hand) motifs and is expressed in the lumen of the endoplasmic reticulum (ER) and Golgi apparatus. In the presence of Ca2+, Calumenin interacts with serum amyloid P component (SAP) and, together, they may play a role in the immunological defense system and participate in amyloidosis, the pathological formation of amyloid deposits in different types of tissues. Calumenin has an inhibitory effect on the vitamin K-dependent g-carboxylation system which converts vitamin K-dependent proteins to Gla-containing proteins. Calumenin may also be involved in the pathophysiology of thrombosis and/or wound healing by acting in an autocrine or paracrine manner.

Purification and Purity: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Calumenin (C-terminus) mAb detects endogenous levels of Calumenin protein.

Bioworld Molecular Weight: Predicted band size:37KDa
Observed band size:45KDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western BlotDetection of CALU in SW480, mouse intestine &A431 cell lysates and using CALU antibody (1:1000 diluted).

Alternative Name: Crocalbin; IEF SSP 9302; CALU

Immunogen: Synthetic peptide, corresponding to amino acids C-terminus of Human Calumenin.

Conjugate: Unconjugated

Modification: Unmodified