SCN1B rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES10279-50, ES10279-100

Citations, Manuals and MSDS Available upon request.

Background: Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009],

Source: Rabbit

Applications: WB; ELISA

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Reactivity: Human; Rat; Mouse

Immunogen: Synthesized peptide derived from part region of human protein

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 23kD

Human Gene ID: 6324

Human SWISS Prot NO: Q07699

Subcellular Location: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Perikaryon. Cell projection. Cell projection, axon. Detected at nodes of Ranvier on the sciatic nerve.; [Isoform 2]: Perikaryon. Cell projection. Secreted. Detected on Purkinje cells and their cell projections and on neuronal cell projections.

Research Use Only