Recombinant Human BCL6/B-cell CLL lymphoma 6 Protein (aa 1-150, His & Trx Tag) Size: 100μg Catalogue Numbers: PKSH030910-100 Citations, Manuals and MSDS Available upon request. Abbreviation: BCL6 Target Synonym: BCL5; BCL6A; LAZ3; ZBTB27; ZNF51 UNIProt ID: P41182 Research Areas: Cancer; epigenetics and nuclear signal Target Species: Human Expression Host: E.coli Fusion Tag: N-Trx-His Accession: P41182 Background: The protein encoded by this gene is an evolutionarily conserved 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain. It has been reported that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines. There are many relationships between non-Hodgkin's lymphoma, diffuse large cell lymphoma and BCL6’ s translocations. BCL6 can repress transcription from promoters linked to its DNA target sequence and this activity is dependent upon specific DNA-binding and the presence of an intact N-terminal half of the protein. Sequence: Met 1-Met 150 Purity: > 92 % as determined by reducing SDS-PAGE. Formulation: Lyophilized from sterile 20mM Tris, 10% glycerol, pH 8.0 Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. Reconstitution: Please refer to the printed manual for detailed information. Endotoxin: Please contact us for more information. Calculated MW: 34.2 kDa Observed MW: 33 kDa Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. Shipping: This product is provided as lyophilized powder which is shipped with ice packs. Research Use Only