SCIENCE+TECHNOLOGY+ARTS: Lessons Learned from a Decade of European Transdisciplinary Innovation documents and reflects on the legacy of the S+T+ARTS Initiative, a pioneering European program that has, since 2016, redefined the interplay of art, science, and technology as a driver of innovation, cultural transformation, and societal change. By uniting contributions from diverse STARTS stakeholders, the book highlights both the achievements and the lessons of a decade of practice, offering valuable knowledge for policymakers, cultural leaders, educators, innovators, and practitioners seeking to replicate or adapt STARTS models in Europe and beyond. Along with it, the publication brings together a wide variety of exemplary artistic projects and best cases that reveal the richness of the STARTS approach. By looking into these experiences, the book highlights how art-science-technology collaborations create impact across sectors, expand ways of thinking, and demonstrate the lasting value of integrating creativity into Europe's innovation ecosystem.